Yes, there are differences between different grades of aluminum sheets. These differences are primarily based on the alloy composition, which affects properties such as strength, formability, and corrosion resistance. For instance, 1000 series aluminum is pure and soft, making it ideal for general purposes. 2000 series is harder and stronger, often used in aerospace applications. 3000 series is known for its high resistance to corrosion and is used in marine applications. 5000 series offers good strength-to-weight ratio and is used in structural applications. 6000 series is known for its strength and is used in construction and industrial applications. Each grade has specific uses based on its unique characteristics.