The most dangerous aspect of what is the additive affect?
The dangerous aspect is the additive one of course! Drink more alcohol, take less drugs. medical-dictionary.thefreediction. An additive effect is the overall consequence which is the result of two chemicals acting together and which is the simple sum of the effects of the chemicals acting independently.
If you mean the synergistic effect (where mixing two kinds of drugs or other controlled substances gives a stronger effect than each one by itself), the danger is that one substance can greatly increase the effectiveness or strength of the other, such that the resulting toxicity is unpredictable. For example, taking depressants and alcohol. The alcohol greatly increases the effectiveness of the depressants, to where you can easily overdose on them without even realizing it.