Safety concerns related to using aluminum profiles in construction include potential corrosion due to exposure to harsh weather conditions, risk of electrical conductivity which may lead to electrocution hazards, and the possibility of thermal expansion and contraction causing structural instability. Additionally, improper installation can lead to structural failure, and the lightweight nature of aluminum may not provide sufficient strength in load-bearing applications. It's crucial to ensure proper design, quality materials, and adherence to safety standards to mitigate these risks.