I have the latest update for my Wii (4.3U) and I can play the game from the game channel but when I load up the game from USB Loader GX it freezes at the loading screen. I have other games on my hard drive and they all work fine.
Trade usb loader gx for usbloadercfg of uloader, they both work better in my opinion. Neogamma will also load games from usb hard drives too.
Just put in the disc for that one....unless you obtained it illegally...then I have no help to offer.