I will be riding a Harley Davidson Seventy Two.
like any bike or car gradual breaking is better, and with a bike, use both front and rear brakes and use your gears to slow down as well,and on wet or greasy roads allow for more braking time to avoid skidding off the road
Not to be a smartazz.but, with your right hand and foot. I also tend to downshift as well. If you are asking about a specific type of situation you may want to list it. From what I remember the only Harleys that had the hand brake on the left, and shifter on the right were some of the early Sportsters.
Gradually apply pressure to the front and rear brake. If the front locks up immediately let go of the brake. If the back locks up keep on the brake. While slowing down downshift and come of the clutch slowly as to not jerk the bike and possibly lose control. Or just stay in gear until your'e going much slower and down shift all the way
Big wheels are just slightly bigger, the engine and everything else is the same. It should be at least. There may big some differences in sprockets, but I don't think so.