Iron absorption in achlorhydria?PPIs and H2RAs increase gastric pH by blocking acid secretions and making the overall gastric contents more alkaline. Subsequently an individual who ate foods rich in iron would not absorb that iron because the food sources need to be converted from ferric to it‘s ferrous formhaving said that.how would a person with achlorhydria alter iron salts like ferrous gluconate, fumurate, and sulfate?? Thanks!
It is true that iron absorption is decreased in achlorhydric states, but there are other factors affecting inorganic iron absorption, for example, the intestinal brush border cells also produce ferric reductase, which can convert the insoluble ferric iron to the ferrous form, especially in the duodenum where majority of the absorption occurs. In clinical practice, achlorhydric states and patients with iron deficiency anemia refractory to oral iron supplements are treated with Parenteral Iron supplements.there are I.M and I.V formulations available. So that's always the other option. Just read your additional details this is my understanding of the process. Dietary iron can be taken in two forms, Organic and Inorganic. Organic iron which is contained in heme, from animal meat sources etc are not subject to the above mechanisms. But in the case of inorganic iron, it needs to be made soluble first in order for absorption to take place. So the insoluble ferric form needs to be reduced to the soluble ferrous form this is where the gastric pH comes into picture. Reduction means addition of hydrogens (or removal of oxygen), so in a low gastric pH, there will be an excess of hydrogen ions, and that will help reduction of ferric to ferrous, thus aiding in absorption. This should be explained in detail in a Medical Physiology book like Guyton. Btw, there have been a lot of papers written investigating achlorhydria and iron absorption, try searching for medical journals.try searching for Omeprazole therapy and iron deficiency this was a highly researched topic because proton pump inhibitors are known to cause achlorhydria. If I remember correctly, none of them give a clear cut causal relationship to iron deficiency, although all suggest a correlation. Best Regards
No, I don't use salt but I do use pepper but not in my cereal.geeeezz BTW I don't like putting sugar in my cereal anyway:D
No, I don't use salt but I do use pepper but not in my cereal.geeeezz BTW I don't like putting sugar in my cereal anyway:D
It is true that iron absorption is decreased in achlorhydric states, but there are other factors affecting inorganic iron absorption, for example, the intestinal brush border cells also produce ferric reductase, which can convert the insoluble ferric iron to the ferrous form, especially in the duodenum where majority of the absorption occurs. In clinical practice, achlorhydric states and patients with iron deficiency anemia refractory to oral iron supplements are treated with Parenteral Iron supplements.there are I.M and I.V formulations available. So that's always the other option. Just read your additional details this is my understanding of the process. Dietary iron can be taken in two forms, Organic and Inorganic. Organic iron which is contained in heme, from animal meat sources etc are not subject to the above mechanisms. But in the case of inorganic iron, it needs to be made soluble first in order for absorption to take place. So the insoluble ferric form needs to be reduced to the soluble ferrous form this is where the gastric pH comes into picture. Reduction means addition of hydrogens (or removal of oxygen), so in a low gastric pH, there will be an excess of hydrogen ions, and that will help reduction of ferric to ferrous, thus aiding in absorption. This should be explained in detail in a Medical Physiology book like Guyton. Btw, there have been a lot of papers written investigating achlorhydria and iron absorption, try searching for medical journals.try searching for Omeprazole therapy and iron deficiency this was a highly researched topic because proton pump inhibitors are known to cause achlorhydria. If I remember correctly, none of them give a clear cut causal relationship to iron deficiency, although all suggest a correlation. Best Regards
