Aluminum sheets with different thicknesses primarily differ in their strength, weight, and applications. Thicker sheets offer greater strength and rigidity, making them suitable for structural applications or heavy-duty uses. In contrast, thinner sheets are lighter and more flexible, ideal for applications requiring formability or where weight is a concern, such as in the automotive or aerospace industries. The choice of thickness depends on the specific requirements of the project, including load-bearing needs, durability, and aesthetic considerations.