Situation: The males in my family have mitral valve prolapse, while I do not.If anyone could answer some of the following questions, it would be amazing! Thank you so much!1. Is this an X or Y chromosome disease? (I thought since it was just guys, it'd b Y)2. If so (or not), is there any reason why I don't have it?Thanks again! (:
I think it could have just skipped you in the generation of it all, it is not always hereditary to every generational child sometimes it will skip a generation and may catch your children when you have some. I know thats not the best news but most of the time thats how it works.
Autosomal dominant inheritance means that the gene carrying a mutation is located on one of the autosomes (chromosome pairs 1 through 22). This means that males and females are equally likely to inherit the mutation. Dominant means that having a mutation in just one of the two copies of a particular gene is all it takes for a person to have a trait, such as an increased risk of developing cancer (see explanation below on variable expressivity and reduced penetrance). When a parent has a dominant gene mutation, there is a 50 percent chance that any child he/she has will also inherit the mutation.
Mitral Valve Prolapse Hereditary
Dear Madam, I am a cardiologist sending this article for you. Hope it helps you. Mitral valve prolapse, sometimes called MVP, is a common heart valve disorder. The mitral valve is between the left atrium and the left ventricle of the heart. It has two leaflets (flaps) that control the blood flow. MVP occurs when one or both of the leaflets are enlarged or have extra tissue. MVP is usually harmless. However, major complications can occur, including a blood clot in the brain and an infection called infective endocarditis involving the mitral valve as well as other valves. MVP appears twice as often in women as in men. It is most commonly a hereditary disorder. Some people with MVP have no symptoms. However, most patients experience a rapid or irregular heartbeat, shortness of breath, light-headedness, and chronic fatigue. Many patients also suffer from migraines, eating and sleeping disorders, an overactive or inflamed thyroid gland, diarrhea, and cold hands and feet. Emotional stress often magnifies the symptoms. Doctors generally prescribe regular exams and aerobic exercise for people who have MVP. Patients also are advised to restrict their intake or use of high-carbohydrate foods, caffeine, and decongestants. Some patients may need beta-blockers and specific antiarrhythmic medication. More severe cases may require surgery to repair or replace the valve or to insert an electronic regulator, such as a pacemaker or defibrillator.
